A case of dermatofibrosarcoma protuberans on the right first toe

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing malignant skin tumor.
• DFSP commonly affects the trunk and extremities, but toe involvement is exceptionally uncommon.

Observation:

• A Japanese woman presented with a hyperkeratotic plaque on her first toe, initially diagnosed as a common wart.
• Treatment with cryotherapy led to the appearance of a glossy, milky-white tumor.

Findings:

• Histopathologic examination confirmed the diagnosis of dermatofibrosarcoma protuberans.
• The unusual macroscopic changes were potentially caused by repeated friction from foot movement.

Implications:

• This case underscores the importance of histopathological analysis for diagnosing rare skin tumors.
• Unusual presentations of DFSP can mimic benign conditions, necessitating careful diagnostic evaluation.