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Related Experiment Videos

Estimating bone change in patients with severe disability

M Takahashi1, H Nagao, H Matsuda

  • 1Department of Paediatrics, Ehime Prefectural Niihama Hospital, Japan.

Developmental Medicine and Child Neurology
|December 1, 1995
PubMed
Summary
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Bone density changes in disabled patients were assessed using microdensitometry (MD) and biochemical markers. Immobilization significantly contributed to bone changes, with elevated urinary hydroxyproline (U-HYP) indicating severity.

Area of Science:

  • Orthopedics
  • Biochemistry
  • Radiology

Background:

  • Severely disabled patients often experience bone changes.
  • Assessing bone health in this population is crucial for management.
  • Existing methods may not fully capture the extent of bone degradation.

Purpose of the Study:

  • To evaluate bone changes in severely disabled patients.
  • To correlate microdensitometry (MD) findings with biochemical markers.
  • To identify key factors contributing to bone degradation.

Main Methods:

  • Bone density was assessed using microdensitometry (MD) on X-ray images.
  • Biochemical markers including urinary hydroxyproline (U-HYP), urinary glycosaminoglycans (U-GAG), serum calcium (S-Ca), and serum alkaline phosphatase (S-AP) were measured.

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  • Patients were categorized into grades 0-3 based on bone change severity using MD.

    • Main Results:

    • Urinary hydroxyproline (U-HYP) was significantly higher in patients with moderate to severe bone changes (grades 2 and 3).
    • Similar trends were observed for urinary glycosaminoglycans (U-GAG) and serum alkaline phosphatase (S-AP).
    • Immobile patients showed significantly higher U-HYP levels compared to mobile patients, highlighting immobilization as a major factor.

    Conclusions:

    • Microdensitometry (MD) is a valuable method for assessing bone changes in severely disabled patients.
    • Biochemical markers like U-HYP and U-GAG are effective indicators of bone degradation.
    • Immobilization is a significant contributor to bone changes in this patient group.