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Porous acrylic cement

A M Rijke, M R Rieger, R E McLaughlin

    Journal of Biomedical Materials Research
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Modifying acrylic bone cement with fillers like sucrose significantly improves performance by reducing heat and monomer release. This creates porous cement ideal for tissue ingrowth, enhancing implant integration.

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    Area of Science:

    • Biomaterials Science
    • Orthopedic Surgery
    • Materials Engineering

    Background:

    • Acrylic bone cement has limitations including high curing temperatures, toxic monomer release, and suboptimal bone bonding.
    • These shortcomings can lead to thermal necrosis and affect implant stability.

    Purpose of the Study:

    • To investigate the modification of acrylic bone cement using soluble, non-toxic fillers.
    • To assess the impact of filler addition on cement properties, including thermal behavior, monomer elution, porosity, and mechanical strength.

    Main Methods:

    • Acrylic bone cement was modified by incorporating fillers such as sucrose and tricalcium phosphate.
    • The workability, curing temperature, monomer release, and porosity of the modified cement were evaluated.
    • Mechanical properties, specifically diametral tensile strength, were measured.

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    Main Results:

    • Filler addition reduced heat generation during curing and decreased monomer elution.
    • A critical filler percentage (20-28 wt% for 125-175 micron sucrose) led to interconnected porosity upon filler elution.
    • Modified cement with up to 40% pores exhibited diametral tensile strength comparable to bone (0.7-1.5 kg/mm²).

    Conclusions:

    • Modifying acrylic bone cement with fillers offers a viable strategy to overcome its inherent limitations.
    • The resulting porous structure promotes tissue ingrowth, potentially improving cement-to-bone bonding.
    • These enhanced cements show promise for orthopedic applications, balancing mechanical integrity with biological integration.