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Related Experiment Videos

Experience with early amniocentesis

K Sundberg1, F S Jørgensen, A Tabor

  • 1Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen, Denmark.

Journal of Perinatal Medicine
|January 1, 1995
PubMed
Summary
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Early genetic amniocentesis, performed before 14-15 weeks, shows comparable diagnostic accuracy to later procedures. The procedure-related loss rate is approximately 1%, similar to standard amniocentesis and chorionic villus sampling.

Area of Science:

  • Prenatal Diagnosis
  • Genetics
  • Obstetrics

Background:

  • Early genetic amniocentesis (before 14-15 weeks) is an evolving area of prenatal diagnosis.
  • Previous studies have examined its safety and diagnostic efficacy compared to later procedures.

Purpose of the Study:

  • To compare early genetic amniocentesis with standard procedures regarding fetal loss rates and cytogenetic data.
  • To evaluate a new filtration method for improving cell yield and reducing culture failure in early amniocentesis.
  • To assess the feasibility of detecting neural tube defects with early amniotic fluid sampling.

Main Methods:

  • Literature review and comparison of published data on early amniocentesis.
  • Analysis of spontaneous fetal loss rates and cytogenetic data.

Related Experiment Videos

  • Development and evaluation of a filtration technique for cell yield enhancement.
  • Ongoing randomized trial to assess the filter technique's efficacy.

    • Main Results:

    • Early amniocentesis demonstrates comparable diagnostic accuracy to later procedures, despite higher initial culture failure rates.
    • A filtration method shows promise in improving cell yield and reducing reporting time for gestational weeks 11-13.
    • Data from nearly 5,000 cases suggest a procedure-related loss rate of approximately 1% for early amniocentesis.
    • Detection of neural tube defects is possible, but its detection rate relative to standard amniocentesis requires further study.

    Conclusions:

    • Early genetic amniocentesis appears to be as safe as standard amniocentesis and chorionic villus sampling, with a similar loss rate.
    • The filtration technique warrants further investigation to optimize early amniocentesis protocols.
    • Continued research is needed to fully establish the diagnostic capabilities and detection rates for neural tube defects in early amniotic fluid sampling.