Dissolution profiles for multisized prednisolone acetate suspensions

Particle-size measurements and in vitro dissolution characteristics of commercial and formulated suspensions of prednisolone acetate were determined using a resistance particle counter and a spinning filter apparatus, respectively. Significant differences in dissolution rates were noted for the commercial suspensions. Particle size affected dissolution but did not account for all observed variations in the dissolution rate. Formulation differences, specifically the presence of hydroxypropyl methylcellulose, in suspensions seemed to be important in dissolution.