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Dissolution profiles for multisized prednisolone acetate suspensions

S A Howard, J W Mauger, L Phusanti

    Journal of Pharmaceutical Sciences
    |April 1, 1977
    PubMed
    Summary
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    Particle size and formulation impact prednisolone acetate suspension dissolution. Hydroxypropyl methylcellulose significantly influenced dissolution rates in this study of commercial and formulated suspensions.

    Area of Science:

    • Pharmaceutical Sciences
    • Physical Pharmacy

    Background:

    • Prednisolone acetate suspensions are common drug formulations.
    • Understanding factors influencing drug release is crucial for efficacy.

    Purpose of the Study:

    • To investigate the impact of particle size and formulation on the in vitro dissolution of prednisolone acetate suspensions.
    • To compare dissolution characteristics of commercial and specifically formulated suspensions.

    Main Methods:

    • Particle-size analysis using a resistance particle counter.
    • In vitro dissolution testing employing a spinning filter apparatus.
    • Evaluation of commercial and formulated prednisolone acetate suspensions.

    Main Results:

    • Significant variations in dissolution rates were observed among commercial prednisolone acetate suspensions.

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  • Particle size was a contributing factor to dissolution rate, but did not fully explain observed differences.
  • The presence of hydroxypropyl methylcellulose in formulations appeared to play a key role in dissolution.

    • Conclusions:

    • Both particle size and formulation excipients influence prednisolone acetate suspension dissolution.
    • Hydroxypropyl methylcellulose is a critical component for controlling dissolution in these formulations.
    • Further research into formulation optimization can enhance drug delivery of prednisolone acetate suspensions.