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A comparative study of the visible light photochemistry of gilvocarcins V and M
A E Alegría1, L Zayas, N Guevara
1Department of Chemistry, CUH Station, University of Puerto Rico at Humacao.
Photochemistry and Photobiology
|September 1, 1995
Abstract:
Quantum yields for the formation of superoxide ions, O2-., and singlet oxygen, 1O2, were determined during the photolyses of gilvocarcin M (GM) in air-saturated dry dimethylsulfoxide (DMSO) and in 45:55 (vol/vol) DMSO-water mixtures. The quantum yield for the photoreduction of methyl viologen by GM in nitrogen-saturated dry DMSO was also determined. These values are not different, within experimental error, from those corresponding to gilvocarcin V (GV). Because GV is a strong photocytotoxic agent and GM is not, these results imply that Type I and Type II mechanisms are not important pathways in the cytotoxicity of GV.