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Intracranial meningiomas: correlation of peritumoral edema and psychiatric disturbances
Abstract:
Patients with proven intracranial meningioma were reexamined for psychiatric morbidity. Distribution according to type of meningioma was as follows: 72% convexity meningiomas and 28% base-of-skull meningiomas. No psychiatric disorders were diagnosed in the nonconvexity group in contrast to 44% in the convexity meningiomas. Among the convexity meningiomas, no difference between right- and left-hemispheric locations was found. Psychiatric comorbidity in the right-hemisphere group was found only in patients with frontal lobe meningiomas. Edema width was measured on all computed tomographic scan slices on which it appeared, and the average of all the slices was calculated. No correlation was found between neurological symptoms and edema severity. A statistically significant correlation was found between edema volume and the presence of coexisting psychiatric disorders, but not between the tumor's mass volume and the psychiatric symptoms.
Insights
Intracranial meningiomas, particularly convexity meningiomas, are linked to psychiatric disorders. Edema volume, not tumor size, correlates with these psychiatric comorbidities in patients.
Area of Science:
- Neurology
- Psychiatry
- Neurosurgery
Background:
- Intracranial meningiomas are common primary brain tumors.
- Psychiatric morbidity can be associated with brain tumors, but specific correlations require further investigation.
Purpose of the Study:
- To investigate the prevalence and characteristics of psychiatric morbidity in patients with intracranial meningiomas.
- To explore the relationship between meningioma location, edema, and psychiatric comorbidities.
Main Methods:
- Retrospective analysis of patients with proven intracranial meningioma.
- Classification of meningiomas into convexity and base-of-skull types.
- Assessment of psychiatric disorders and correlation with tumor characteristics, including location and edema volume measured via computed tomography (CT).
Main Results:
- 44% of patients with convexity meningiomas exhibited psychiatric disorders, compared to none in the base-of-skull group.
- No laterality difference was observed for convexity meningiomas, but frontal lobe meningiomas in the right hemisphere were associated with psychiatric comorbidity.
- A significant correlation was found between edema volume and the presence of psychiatric disorders, independent of tumor mass volume.
Conclusions:
- Convexity meningiomas are more frequently associated with psychiatric disorders than base-of-skull meningiomas.
- Edema volume is a significant factor associated with psychiatric comorbidities in intracranial meningioma patients.
- Further research is warranted to understand the mechanisms linking meningiomas, edema, and psychiatric symptoms.