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[Human parvovirus B19 infection. Update]

M Karmochkine1

  • 1Service de médecine interne, CHU Pitié-Salpêtrière, Paris, France.

La Revue De Medecine Interne
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Parvovirus B19 causes various illnesses, including erythema infectiosum in children and arthritis in adults. It targets red blood cells, leading to aplastic crisis or red cell aplasia in vulnerable patients.

Area of Science:

  • Virology
  • Immunology
  • Hematology

Context:

  • Parvovirus B19 is a human pathogen with diverse clinical presentations.
  • Disease severity and manifestations depend on patient age and immune status.

Purpose:

  • To outline the pathogenicity and clinical spectrum of parvovirus B19 infection.
  • To highlight diagnostic methods and treatment considerations for parvovirus B19.

Summary:

  • Parvovirus B19 causes erythema infectiosum in children and arthritis in adults.
  • It targets erythroid precursors, leading to aplastic crisis or chronic pure red cell aplasia in specific patient groups.
  • Severe manifestations include hydrops fetalis; diagnosis relies on serology and PCR, with intravenous immunoglobulin therapy for immunosuppressed individuals.

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Impact:

  • Clarifies the varied clinical impact of parvovirus B19 across different populations.
  • Emphasizes diagnostic approaches and management strategies for parvovirus B19 infections.
  • Raises questions regarding the association between parvovirus B19 and systemic vasculitis.