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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
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[The interferon status and cellular immunity of pregnant women with viral hepatitis B]

M D Akhmedova, A V Zmyzgova, M T Karimova

    Terapevticheskii Arkhiv
    |January 1, 1995
    PubMed

    The examination of 62 pregnant women with acute viral hepatitis B has established in them inhibition of interferon genesis and the presence of secondary T-cell immunodeficiency. The most pronounced and long-lasting was a fall of gamma-interferon. A simultaneous lowering of alpha-, gamma- and serum interferon was indicative of complicated pregnancy or premorbid condition. A persistent deficient production of gamma-interferon and T lymphocytes, imbalance of their subpopulations promoted long-term course of hepatitis and persistence of HBsAg.

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