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Nutritional intervention to prevent hereditary cancer
1Cancer Prevention Studies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7326, USA.
Journal of the National Cancer Institute. Monographs
|January 1, 1995
Summary
Nutritional interventions show promise for cancer prevention, with potential variations based on genetic susceptibility. Future research aims to link these interventions with genetic markers to understand gene-environment interactions in cancer development.
Area of Science:
- Oncology
- Nutritional Science
- Genetics
Background:
- Emerging clinical trials suggest selected antioxidants may aid in primary cancer prevention.
- Identification of genetic susceptibility markers for various cancers is advancing.
Purpose of the Study:
- To investigate if nutritional interventions' cancer prevention effects vary based on genetic susceptibility.
- To explore gene-environment interactions in cancer development.
Main Methods:
- Review of recent large clinical trials on nutritional interventions for cancer prevention.
- Consideration of identified genetic susceptibility markers.
- Examination of preliminary animal data on calorie restriction and tumor mortality.
Main Results:
- Apparent efficacy of certain antioxidants in preventing esophageal, stomach, prostate, and colorectal cancers.
- Preliminary animal studies indicate calorie restriction may reduce tumor mortality in p53-knockout mice.
Conclusions:
- Linking nutritional intervention outcomes with genetic susceptibility markers is crucial.
- Understanding gene-environment interactions can refine cancer prevention strategies.