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Topical photodynamic therapy in verrucae. A pilot study
R Ammann1, T Hunziker, L R Braathen
1Department of Dermatology, Inselspital, University of Berne, Switzerland.
Dermatology (Basel, Switzerland)
|January 1, 1995
Summary
Topical photodynamic therapy (PDT) is likely ineffective for treating stubborn warts (verrucae vulgares). This pilot study found only one of six patients achieved a complete response to 5-aminolevulinic acid-PDT.
Area of Science:
- Dermatology
- Photomedicine
- Oncology
Background:
- Topical photodynamic therapy (PDT) demonstrates efficacy in treating solar keratoses and superficial skin cancers.
- Verrucae vulgares represent a common dermatological condition often requiring effective treatment options.
Purpose of the Study:
- To evaluate the efficiency and tolerance of topical photodynamic therapy (PDT) for refractory verrucae vulgares.
- To assess the potential of 5-aminolevulinic acid-PDT as a treatment for recalcitrant warts.
Main Methods:
- An open-label pilot study was conducted.
- Six patients with verrucae vulgares received treatment with 5-aminolevulinic acid-PDT.
- Patients were monitored for a 2-month follow-up period.
Main Results:
- A complete treatment response was observed in only one out of six patients.
- The remaining five patients were classified as treatment failures.
- The study indicated limited efficacy of topical PDT for verrucae vulgares.
Conclusions:
- Topical photodynamic therapy (PDT) appears to be inefficient for treating verrucae vulgares.
- Further research may be needed to explore alternative or combination therapies for refractory warts.