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Animal models of protective immunity in tuberculosis to evaluate candidate vaccines
J F Griffin1, C G Mackintosh, G S Buchan
1Dept of Microbiology, University of Otago, Dunedin, New Zealand. frank.griffin@stonebow.otago.ac.nz
Trends in Microbiology
|November 1, 1995
Abstract:
While the etiology of tuberculosis is well understood, the nature of the protective immune response to the causative mycobacteria has remained a mystery. There is an urgent need to define protective immunity critically, and to develop alternative animal models to evaluate the efficacy of new-generation vaccines against tuberculosis in a cost-effective way.