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Acylfulvenes, a new class of potent antitumor agents
T C McMorris1, M J Kelner, W Wang
1Department of Chemistry, University of California, San Diego, La Jolla 92093-0506, USA.
Experientia
|January 16, 1996
Abstract:
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to thiols than illudin S. However, it is reduced readily to an aromatic product, in the same way as illudin S. This may explain its greatly improved therapeutic index compared to that of the parent compound.