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Clinical, hormonal and sonographic predictors of successful RU-486-induced abortions
1Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Gynecologic and Obstetric Investigation
|January 1, 1995
Summary
Early sonographic findings, specifically a small hematoma, may predict successful RU-486 medical abortions. This method, alongside hormonal changes, aids in assessing treatment outcomes for women undergoing mifepristone-induced abortion.
Area of Science:
- Reproductive Medicine
- Pharmacology
Background:
- Medical abortion using mifepristone (RU-486) is a common procedure.
- Predicting successful outcomes is crucial for patient management.
Purpose of the Study:
- To determine the best predictor of successful RU-486-induced abortions among clinical, hormonal, and sonographic methods.
- To identify early indicators of successful medical abortion.
Main Methods:
- Studied 20 healthy women (6-9 weeks gestation) desiring abortion.
- Assessed clinical, hormonal (estradiol, progesterone, cortisol), and sonographic parameters.
- Compared findings between women who successfully aborted and those who did not.
Main Results:
- 14 women (70%) successfully aborted; 6 (30%) failed.
- Successful abortions were associated with a small hematoma (decidual capsularis detachment) on early ultrasound.
- Successful aborters showed decreased estradiol/progesterone and increased cortisol by day 7; non-aborters showed no significant changes.
Conclusions:
- Early sonographic findings, such as a small hematoma, may predict successful RU-486 administration.
- Hormonal changes (decreased estradiol/progesterone, increased cortisol) correlate with successful medical abortion.
- Sonographic assessment appears valuable for early prediction of RU-486 treatment success.
