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Updated: Jul 25, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Population pharmacokinetics of teicoplanin in patients with endocarditis

D K Yu1, E Nordbrock, S J Hutcheson

  • 1U.S. Pharmacokinetics Department, Hoechst Marion Roussel, Inc., Kansas City, Missouri 64137, USA.

Journal of Pharmacokinetics and Biopharmaceutics
|February 1, 1995
PubMed

Insights

Teicoplanin, a glycopeptide antibiotic, effectively treats gram-positive bacterial infections. Population pharmacokinetic modeling identified body weight, creatinine, and co-administered drugs as key factors influencing teicoplanin clearance and distribution.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Teicoplanin is a novel glycopeptide antibiotic with activity against aerobic and anaerobic gram-positive bacteria.
  • It is indicated for treating systemic infections, including endocarditis.

Purpose of the Study:

  • To characterize the population pharmacokinetics of teicoplanin in patients undergoing treatment for systemic infections.
  • To identify patient-specific factors influencing teicoplanin pharmacokinetics.

Main Methods:

  • Two U.S. clinical trials involving 197 patients receiving teicoplanin.
  • Pharmacokinetic data analyzed using nonlinear mixed-effects modeling (NLME) with a two-compartment model.
  • Serum teicoplanin concentrations monitored using fluorescence polarization immunoassay (FPIA) and microbiological assay.

Main Results:

  • Teicoplanin population pharmacokinetics were best described by a two-compartment model.
  • Significant factors influencing systemic clearance (CL) included patient body weight, concomitant gram-positive drug treatment, and serum creatinine.
  • Body weight also impacted the central compartment volume of distribution (Vc).
  • The FPIA assay demonstrated higher precision compared to the microbiological assay.

Conclusions:

  • Patient body weight, serum creatinine, and concurrent antibiotic therapy are crucial covariates for teicoplanin dosing.
  • Understanding these factors can optimize teicoplanin therapy and improve patient outcomes.
  • FPIA is a more precise method for monitoring serum teicoplanin concentrations.

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