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Related Experiment Videos

Tissue factor expression in human leukocytes and tumor cells

F R Rickles1, G A Hair, R A Zeff

  • 1Division of HIV/AIDS, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

Thrombosis and Haemostasis
|July 1, 1995
PubMed
Summary

Tissue factor (TF) is expressed in tumor cells and linked to blood clotting in disease. Cellular glycosylation may regulate TF expression, impacting its role in leukemia and bleeding complications.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Hematology

Background:

  • Tissue factor (TF) is typically inactive in blood monocytes but active in tumor cells.
  • TF expression on cell surfaces correlates with coagulation activation in inflammatory and malignant diseases.
  • Complex regulation of TF synthesis is influenced by cellular pathways.

Purpose of the Study:

  • To review the regulation of TF synthesis and expression.
  • To explore the role of cellular glycosylation in TF function.
  • To understand TF's involvement in thrombohemorrhagic complications, particularly in leukemia.

Main Methods:

  • Review of existing literature on TF synthesis and regulation.
  • Analysis of transfection studies investigating TF gene expression.

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  • Examination of cellular glycosylation pathways and their impact on TF.

    • Main Results:

    • Constitutive TF expression in tumor cells is linked to coagulation.
    • Dysregulation of TF synthesis, potentially due to altered glycosylation, affects its cell surface expression.
    • Impaired glycosylation may explain lineage-unfaithful TF expression in leukemic cells.

    Conclusions:

    • Cellular glycosylation significantly impacts the expression and function of Tissue Factor.
    • Dysregulation of TF glycosylation may contribute to thrombohemorrhagic complications in diseases like acute progranulocytic leukemia.
    • Further research into TF carbohydrate modification is crucial for understanding its role in disease.