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Differentiation of extramedullary acute promyelocytic leukemia by all-trans-retinoic acid
C A Lederman1, J Weisberger, K Seiter
1Division of Oncology/Hematology, New York Medical College, Valhalla, New York 10595, USA.
Leukemia & Lymphoma
|June 1, 1995
Abstract:
The effect of all-trans-retinoic acid (ATRA) on extramedullary acute promyelocytic leukemia (APL) has not been fully delineated. We report an unusual case of APL in which a patient relapsed in the skin and central nervous system. Cytodifferentiation of leukemic cells from these extramedullary sites was demonstrated following treatment with ATRA.