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[Immunological status of the pediatric patient who has undergone heart surgery]
A Valenzuela Flores1, G Wakida, A Limón Rojas
1Servicio de Pediatría, Hospital Infantil Central Sur de Alta Especialidad de Petróleos Mexicanos, México, DF.
Insights
Open and closed-heart surgery temporarily weakened the immune system in pediatric patients. Immune function recovered by the fifth day after surgery, indicating a transient immunodeficiency.
Area of Science:
- Immunology
- Pediatric Surgery
- Cardiovascular Surgery
Context:
- Investigated the impact of open-heart and closed-heart surgery on the immune system of pediatric patients.
- Data collection occurred pre-operatively and five days post-operatively.
- Study conducted at Hospital Central de Petróleos Mexicanos (PEMEX) in Mexico City.
Purpose:
- To evaluate the immunological effects of open and closed-heart surgery in children.
- To assess changes in immune cell counts and serum immunoglobulin levels post-surgery.
Summary:
- Pediatric patients undergoing open or closed-heart surgery exhibited increased neutrophil counts and lymphopenia.
- Serum complement components (C3, C4) and immunoglobulins (IgG, IgA, IgM) showed transient elevations post-surgery.
- Two patients developed surgical wound infections; overall, a temporary immunodeficiency was observed with immune system recovery by day five.
Impact:
- Highlights the transient immunodeficiency following pediatric cardiac surgery.
- Provides insights into immune system response and recovery in young patients.
- Informs clinical management and monitoring of pediatric patients undergoing cardiac procedures.
Unlabelled:
Communication of results a study the effect of open and closed-heart surgery in the immune system of infants and children. Data collected 24 hrs before anesthesia and surgery and five days after surgery. Operating room and pediatric intensive care of Hospital Central de Petróleos Mexicanos (PEMEX) in the South, Mexico City. Children undergoing surgery for correction of congenital heart disease (age 16 months to 14 years). A total of 16 patients.
Measurements And Results:
increased neutrophil counts with luymphopenia in both groups (p < 0.05), serum levels of the complement components C3 and C4 were higher after surgery, serum immunoglobulin IgG, IgA and IgM were higher after surgery, serum immunoglobulin IgG, IgA and IgM were decreased form preoperative levels (p < 0.01). Two patients had infection in the surgical wound. The effect of open and closed-heart surgery produced transitory immunodeficiency with recuperation of his immune systems and 5th day after surgery.