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Internet-based support for bioscience research: a collaborative genome center for human chromosome 12
P L Miller1, P M Nadkarni, K K Kidd
1Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520-8009. perry_miller@yale.edu
Journal of the American Medical Informatics Association : JAMIA
|November 1, 1995
Summary
This study details an Internet-based system for collaborative human chromosome 12 mapping, integrating shared databases and analysis tools for genome informatics. It highlights medical informatics
Area of Science:
- Genomic informatics
- Medical informatics
- Collaborative bioscience research
Background:
- Genome mapping requires robust informatics infrastructure.
- Internet-based collaboration is crucial for large-scale genomics projects.
- Previous approaches lacked integrated support for collaborative mapping efforts.
Purpose of the Study:
- To introduce medical informatics professionals to genome informatics challenges.
- To present a case study of Internet-based support for collaborative genome mapping.
- To explore the role of medical informatics in supporting bioscience research.
Main Methods:
- Development of a shared database (DB/12) with a user-friendly front end.
- Utilizing yeast artificial chromosomes (YACs) to map human DNA segments.
- Implementation of a map assembly tool for data interpretation.
Main Results:
- Successful mapping of human chromosome 12 through inter-institutional collaboration.
- Identification of contigs and marker ordering using the shared database.
- Integration of the database with external tools and dissemination of results.
Conclusions:
- Internet-based informatics systems are vital for collaborative genome mapping.
- Medical informatics can play a significant role in advancing bioscience research.
- Lessons learned from this project are applicable to other collaborative bioscience endeavors.