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Biologically active principles isolated from Salacia oblonga wall
K T Augusti1, P Joseph, T D Babu
1Amala Cancer Research Centre, Thrissur.
Indian Journal of Physiology and Pharmacology
|October 1, 1995
Summary
The root bark of Salacia Oblonga wall contains compounds with significant anti-cancer and anti-diabetic properties. These findings highlight the plant
Area of Science:
- Pharmacology and Phytochemistry
- Natural Product Chemistry
Background:
- Salacia Oblonga wall is a plant with a history of traditional medicinal use.
- Investigating the bioactive compounds in medicinal plants is crucial for drug discovery.
Purpose of the Study:
- To isolate and characterize biologically active compounds from the root bark of Salacia Oblonga wall.
- To evaluate the cytotoxic and hypoglycemic potential of these isolated compounds.
Main Methods:
- Extraction of Salacia Oblonga wall root bark using petroleum ether.
- Isolation of active fractions using column and thin-layer chromatography (TLC).
- Cytotoxicity assay on Ehrlich ascites tumor cells and hypoglycemic assay in albino rats.
Main Results:
- A methanol-eluted fraction exhibited 100% cytotoxicity against Ehrlich ascites tumor cells.
- A chloroform-eluted fraction and a fluorescent compound showed 60% and 76% hypoglycemic potency, respectively, compared to tolbutamide.
- These results indicate significant biological activity of the isolated compounds.
Conclusions:
- The study successfully identified bioactive compounds from Salacia Oblonga wall.
- These compounds demonstrate potent cytotoxic and hypoglycemic effects, suggesting therapeutic potential.
- Salacia Oblonga wall is a promising source for developing new anti-cancer and anti-diabetic agents.