Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary central nervous system lymphoma

R J Freilich1, L M DeAngelis

  • 1Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Neurologic Clinics
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pilot study of neuropsychological functions, APOE and amyloid imaging in patients with gliomas.

Journal of neuro-oncology·2017
Same author

OC-02 - Risk of arterial thromboembolism in patients with breast cancer.

Thrombosis research·2016
Same author

Multimodality imaging of primary CNS lymphoma in immunocompetent patients.

The British journal of radiology·2014
Same author

Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma.

Leukemia·2011
Same author

Intracranial hemorrhage in patients with cancer treated with bevacizumab: the Memorial Sloan-Kettering experience.

Annals of oncology : official journal of the European Society for Medical Oncology·2011
Same author

Leptomeningeal metastases in the MRI era.

Neurology·2010

Primary CNS lymphoma (PCNSL) is increasingly understood, but treatment requires considering CNS dissemination and blood-brain barrier challenges. Chemotherapy improves outcomes, yet PCNSL prognosis lags behind systemic lymphomas, driving research for less toxic therapies.

Area of Science:

  • Neuro-oncology
  • Hematology
  • Clinical Medicine

Background:

  • Primary CNS lymphoma (PCNSL) incidence is rising, enhancing understanding of its clinical features.
  • PCNSL presents unique challenges including CNS dissemination, blood-brain barrier penetration, and leptomeningeal/ocular involvement.
  • Effective treatment protocols must address these specific disease characteristics.

Purpose of the Study:

  • To review the clinical features and behavior of primary CNS lymphoma.
  • To discuss factors influencing treatment protocol design for PCNSL.
  • To highlight the impact of chemotherapy and future directions in PCNSL management.

Main Methods:

  • Literature review of PCNSL clinical features and treatment outcomes.
  • Analysis of factors affecting treatment strategies, including dissemination and blood-brain barrier.

Related Experiment Videos

  • Evaluation of chemotherapy's role and comparison with systemic lymphomas.

    • Main Results:

    • Chemotherapy has significantly impacted PCNSL treatment efficacy.
    • Despite advances, PCNSL prognosis remains poorer than comparable systemic non-Hodgkin's lymphomas.
    • Treatment design must account for CNS-specific factors like tumor spread and blood-brain barrier.

    Conclusions:

    • Continued development of chemotherapy regimens is crucial for improving PCNSL survival.
    • The goal is to enhance survival while minimizing neurotoxic effects of radiation therapy.
    • Further research is needed to optimize PCNSL treatment and improve patient outcomes.