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Changes of some biochemical and hematological parameters following administration of daunorubicin in rabbits
1Department of Pharmacology, Faculty of Medicine Charles University, Hradec Králové.
Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove
|January 1, 1995
Abstract:
The effects of the repeated i.v. administration of daunorubicin (50 mg/m2, once weekly, max. 9 weeks) were investigated in rabbits in vivo to analyze biochemical and hematological changes. Noninvasive polygraphic records were used to evaluate the function of the heart. The administration of daunorubicin induced changes especially in levels of protein (decrease in total protein and albumin) and of some ions (decrease in calcium, magnesium and phosphorus) as well as in hematological parameters (decrease in erythrocytes, leukocytes and thrombocytes). The results obtained correlate with data on mechanisms of daunorubicin toxicity.