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Intraocular pressure decrease after local ocular cooling is underestimated by applanation tonometry

S Orgül1, J Flammer, D Stümpfig

  • 1University Eye Clinic, Basel, Switzerland.

International Ophthalmology
|January 1, 1995
PubMed
Summary
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Local eye cooling in humans decreases intraocular pressure (IOP), but this effect can be masked by cooling-induced corneal thickening. Further research is needed to understand the full impact of temperature on ocular physiology.

Area of Science:

  • Ophthalmology
  • Physiology

Background:

  • Systemic or local cooling affects aqueous humor dynamics, increasing outflow facility and decreasing flow.
  • Previous human studies suggest local cooling decreases intraocular pressure (IOP) due to episcleral vasculature vasoconstriction.
  • Corneal changes may have influenced prior research, necessitating assessment in normal subjects.

Purpose of the Study:

  • To evaluate the effect of local ocular cooling on intraocular pressure and corneal thickness in healthy human subjects.
  • To investigate the relationship between cooling-induced corneal changes and IOP modulation.

Main Methods:

  • 18 healthy subjects underwent measurements of IOP and corneal thickness.
  • The right eye of each subject was exposed to controlled air streams at 20°C and 0°C.

Related Experiment Videos

  • Data were collected before and after cooling exposure.

    • Main Results:

    • No significant changes in IOP or corneal thickness were observed at 20°C.
    • Local cooling to 0°C significantly increased corneal thickness (0.52 to 0.57 mm).
    • Mean IOP decreased from 13.8 to 12.9 mmHg post-cooling, correlating negatively with corneal thickening.

    Conclusions:

    • The eye exhibits high sensitivity to local cooling.
    • Cooling-induced corneal thickness changes can partially mask the true effect of local cooling on IOP.
    • The observed IOP reduction may be underestimated due to concurrent corneal hydration changes.