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[Neutron activation analysis of biological samples]
A Ohta1, F Siraishi, T Nagahara
1Department of Radiology, Kitasato University School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 1, 1996
Summary
Neutron activation analysis (NAA) quantifies trace elements in biological samples, aiding medical research. This method successfully determined 12 elements, including a fluorinated anti-cancer drug, in human tissues and serum.
Area of Science:
- Nuclear Chemistry
- Analytical Chemistry
- Biomedical Science
Context:
- Neutron activation analysis (NAA) is a powerful technique for multi-element determination.
- Medical applications require sensitive and accurate quantification of trace elements in biological matrices.
- Previous studies have explored NAA for elemental analysis in biological samples.
Purpose:
- To discuss multi-element analysis using NAA for medical applications.
- To demonstrate the determination of trace elements in human pathological liver tissues, human serum, and rat liver.
- To present a sensitive NAA method for quantifying fluorinated drugs in human serum.
Summary:
- Biological samples (human liver, serum, rat liver) were analyzed using NAA.
- Irradiation was performed for short (10s, 5min) and long (24hr) durations in research reactors.
- Concentrations of 12 elements (e.g., I, Mn, Cu, Na, K, Cl, Al, Ca, S, Fe, Zn) were determined, along with the anti-cancer drug Futraful (19F) and calcium uptake (48Ca).
Impact:
- Provides a sensitive method for trace element analysis in biological samples relevant to medicine.
- Enables the study of elemental composition in pathological tissues and drug clearance in serum.
- Contributes to understanding biological processes like calcium uptake in liver tissue.