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Related Experiment Videos

Cyclosporine A stimulates endothelin release

C Haug1, T Duell, R Voisard

  • 1Institute of Clinical Chemistry, University of Ulm, Germany.

Journal of Cardiovascular Pharmacology
|January 1, 1995
PubMed
Summary

Cyclosporine A increases endothelin (ET) release from smooth muscle cells and elevates ET plasma levels in patients. This suggests ET contributes to cyclosporine

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Area of Science:

  • Pharmacology
  • Nephrology
  • Cardiovascular Medicine

Background:

  • Cyclosporine A administration is linked to renal dysfunction and hypertension.
  • Endothelin (ET) is implicated in mediating cardiovascular and renal side effects of cyclosporine.

Purpose of the Study:

  • To investigate cyclosporine A's influence on ET release from cultured smooth muscle cells.
  • To determine if ET plasma concentrations are elevated in cyclosporine-treated patients.

Main Methods:

  • Cultured human smooth muscle cells from atherosclerotic iliac arteries were treated with cyclosporine A.
  • ET plasma levels were measured in cyclosporine-treated bone marrow transplant patients and compared to controls.

Main Results:

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  • Cyclosporine A induced a dose-dependent increase in ET release from cultured smooth muscle cells.
  • ET plasma levels were significantly elevated in cyclosporine-treated patients post-bone marrow transplantation.

    • Conclusions:

    • Enhanced ET release may mediate cyclosporine-associated cardiovascular and renal side effects.
    • Endothelin plays a role in the adverse effects of cyclosporine therapy.