Effect of a new cognitive drug-enhancer S-12024-2 on EEG sleep recordings in rats

A newly synthesized agent S-12024-2 was shown to improve some aspects of cognitive processes such as memory consolidation. The relationships between sleep and memory lead us to investigate the effects of the intraperitoneal administration of three different doses (1, 3, and 10 mg/kg) of S-12024-2 on sleep variables in the rat. The results showed that S-12024-2 (10 mg/kg) increased slow wave sleep (SWS) and decreased wakefulness during the light period of the first 24 h of sleep recording. During day 1 of sleep recording, S-12024-2 tended to increase paradoxical sleep (PS) with a maximal effect observed with 3 mg/kg. Four days after administration of S-12024-2 (3 mg/kg), PS remained significantly high. These data suggest an active role for S-12024-2 on SWS and PS, compatible with its favourable effects on memory.