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Novel prostanoid thromboxane A2 agonists
K D Joachim1, U Klar, A Pletsch
1Research Laboratories of Schering AG, Berlin, Germany.
Prostaglandins
|August 1, 1995
Abstract:
The chemistry and biology of novel TXA2(TP)-receptor agonists based on the prostanoid skeleton is described and structure-activity-relationships are discussed. One compound,(5Z,13E), (9R,15R)-9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid (33), was identified which is 10 times more potent than the standard TP-receptor against U 46619.