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Updated: Aug 17, 2026

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A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
Published on: January 20, 2023
The influence of proline analogs on bleomycin-induced lung injury in rats
1Department of Pathophysiology, Veterinary Faculty of Agricultural Academy, Lublin, Poland.
Acta Physiologica Hungarica
|January 1, 1995
Abstract:
The influence of 3,4-dehydro-DL-proline and 3,4-dehydro-L-proline on lysyl oxidase, prolyl hydroxylase activities, collagen cross-linking and types of collagen in bleomycin-induced lung injury was investigated. Both proline analogs cause a great fall in prolyl hydroxylase activity without effect on lysyl oxidase, diminish the number of cross-links and normalize the type I/type III collagen ratio. It is suggested that proline analogs may be valuable agents in lung fibrosis treatment.

