Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Familial cutaneous melanoma

L C Lucchina1, R L Barnhill, D M Duke

  • 1Department of Dermatology, Massachusetts General Hospital, Boston 02114, USA.

Melanoma Research
|December 1, 1995
PubMed
Summary

A family history of melanoma significantly impacts risk. Subsequent melanoma diagnoses within families tend to be thinner, highlighting the importance of screening and surveillance for melanoma patients and their relatives.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The pink papules and plaques of Spitz.

The British journal of dermatology·2019
Same author

Skin biopsy utilization and melanoma incidence among Medicare beneficiaries.

The British journal of dermatology·2016
Same author

Festschrift in honor of Dr. Thomas B. Fitzpatrick.

The Journal of investigative dermatology·2010
Same author

Early death from clinical stage I melanoma.

The Journal of investigative dermatology·2010
Same author

Factors associated with death from melanoma from 2 to 5 years following diagnosis in clinical stage I patients.

The Journal of investigative dermatology·2010
Same author

C16 laminin peptide increases angiotropic extravascular migration of human melanoma cells in a shell-less chick chorioallantoic membrane assay.

The British journal of dermatology·2007

Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Family history is a significant risk factor for cutaneous malignant melanoma.
  • Understanding the clinical characteristics of familial melanoma is crucial for risk assessment and management.

Purpose of the Study:

  • To evaluate the clinical characteristics of patients with cutaneous familial melanoma.
  • To analyze lesion thickness trends within families affected by melanoma.

Main Methods:

  • Retrospective chart review of 102 patients from 49 families with cutaneous melanoma.
  • Data collected from Massachusetts General Hospital Pigmented Lesion Clinic over an 8-year period.
  • Analysis of personal/family history of dysplastic nevi and primary melanoma thickness.

Main Results:

  • 82% of patients had a history of dysplastic nevi.
  • Subsequent affected individuals within families had thinner primary melanomas compared to initial diagnoses.
  • 17% had multiple primary melanomas, with later lesions being significantly thinner.
  • Patients with one primary melanoma had thicker lesions than those with multiple primaries.

Conclusions:

  • Family history verification is essential for melanoma risk assessment.
  • Screening and surveillance are recommended for all melanoma patients and their family members.
  • Early detection and monitoring can lead to thinner melanomas in familial cases.

Related Experiment Videos