Related Experiment Videos
Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus
Y R Cheng1, A Fang, A L Demain
1Fermentation Microbiology Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA.
Applied Microbiology and Biotechnology
|November 1, 1995
Abstract:
In a chemically defined medium containing aspartate, arginie and histidine to support good growth, addition of L-lysine stimulated rapamycin production by 150%. This was probably due to its conversion to pipecolic acid, a rapamycin precursor. Phenylalanine and methionine interfered in rapamycin production by unknown mechanisms.