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Rapamycin (sirolimus, rapamune)
S N Sehgal1, J S Camardo, J A Scarola
1Division of Endothelial Cell and Cytokine Biology, Wyeth-Ayerst Research, Princeton, New Jersey, USA.
Current Opinion in Nephrology and Hypertension
|November 1, 1995
Abstract:
Rapamycin is a novel immunosuppressive agent that is undergoing clinical trials for use in allograft rejection therapy. This paper reviews its in-vitro biological properties, the current state of knowledge concerning its mechanism of action, and its therapeutic applications.