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Related Experiment Videos

Meperidine effects on schedule-controlled responding

J D Leander, D E McMillan

    The Journal of Pharmacology and Experimental Therapeutics
    |May 1, 1977
    PubMed
    Summary
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    Meperidine

    Area of Science:

    • Pharmacology
    • Behavioral Neuroscience

    Background:

    • Opioid drugs like meperidine are frequently used for pain management.
    • Understanding the behavioral effects and mechanisms of opioids is crucial for clinical practice.

    Purpose of the Study:

    • To investigate the dose-dependent effects of meperidine on operant responding in pigeons.
    • To examine the potential antagonism of meperidine's effects by opioid antagonists and cross-tolerance with methadone.

    Main Methods:

    • Pigeons were trained on a multiple fixed-ratio, fixed-interval schedule of food presentation.
    • Meperidine was administered at various doses, and its effects on response rates were recorded.
    • Naloxone, cyclazocine, and methadone were used to assess antagonism and cross-tolerance.

    Related Experiment Videos

    Main Results:

    • Low doses of meperidine increased responding under the fixed-interval schedule, while higher doses decreased responding under both fixed-ratio and fixed-interval schedules.
    • Naloxone partially antagonized the rate-increasing effects of meperidine, but neither naloxone nor cyclazocine antagonized the rate-decreasing effects.
    • Meperidine did not exhibit cross-tolerance with methadone, indicating distinct pharmacological mechanisms.

    Conclusions:

    • The rate-decreasing effects of meperidine are not mediated by typical opioid receptors targeted by naloxone and cyclazocine.
    • Meperidine's distinct pharmacological profile suggests it may not share the same tolerance development pathways as methadone.