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The 23S Ribosomal RNA Mutation Database (23SMDB)

K L Triman1

  • 1Department of Biology, Franklin and Marshall College, Lancaster, PA 17604, USA.

Nucleic Acids Research
|January 1, 1996
PubMed
Summary

The 23S Ribosomal RNA Mutation Database (23SMDB) catalogs mutations in Escherichia coli 23S ribosomal RNA. It details mutation phenotypes, detection methods, and literature for researchers.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Ribosomal RNA (rRNA) is crucial for protein synthesis.
  • Mutations in 23S rRNA can affect bacterial function and antibiotic resistance.
  • A centralized resource for 23S rRNA mutations is needed.

Purpose of the Study:

  • To establish a comprehensive database of 23S ribosomal RNA mutations in Escherichia coli.
  • To provide detailed information on mutation-associated phenotypes and experimental validation.
  • To facilitate research on 23S rRNA function and genetic alterations.

Main Methods:

  • Compilation of mutation data from scientific literature.
  • Annotation of mutation positions and alterations in 23S rRNA.
  • Inclusion of phenotype descriptions and detection methods (in vivo/in vitro).

Main Results:

  • The 23S Ribosomal RNA Mutation Database (23SMDB) lists identified mutations.
  • Each entry includes mutation identity, associated phenotypes, and detection context.
  • Relevant scientific literature citations are provided for each mutation.

Conclusions:

  • The 23SMDB serves as a valuable resource for studying 23S rRNA mutations.
  • It supports research into bacterial genetics, protein synthesis, and drug resistance mechanisms.
  • The database is accessible via FTP and the World Wide Web.

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