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The PIR-International Protein Sequence Database

D G George1, W C Barker, H W Mewes

  • 1Protein Information Resource, National Biomedical Research Foundation, Washington, DC 20007, USA.

Nucleic Acids Research
|January 1, 1996
PubMed
Summary
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The Protein Sequence Database, established in 1988, provides comprehensive, quality-controlled protein sequence data. This internationally collaborative resource is accessible globally, supporting biological research and integrated into major bioinformatics systems.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Biotechnology

Background:

  • The Protein Sequence Database was initiated to support scientific research.
  • It emphasizes comprehensive data coverage, quality control, and biological organization.
  • Database maintenance has been a collaborative effort since 1988.

Purpose of the Study:

  • To describe the Protein Sequence Database's design and collaborative maintenance.
  • To highlight its accessibility and widespread distribution.
  • To underscore its role in supporting biological research.

Main Methods:

  • Collaborative maintenance through PIR-International, an association of macromolecular sequence data centers.
  • Data organization based on biological principles.

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  • Distribution via multiple platforms including the World Wide Web, FTP, email, CD-ROM, and magnetic media.

    • Main Results:

    • The database offers comprehensive, quality-controlled protein sequence data.
    • It is maintained collaboratively by PIR-International.
    • The data is widely distributed and accessible through various channels.

    Conclusions:

    • The Protein Sequence Database is a vital, internationally supported resource for biological research.
    • Its comprehensive nature, quality control, and accessibility make it a foundational tool.
    • The database is integrated into other major bioinformatics systems, enhancing its utility.