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The RNA modification database

P F Crain1, J A McCloskey

  • 1Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA.

Nucleic Acids Research
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

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The RNA Modification Database lists RNA nucleosides, detailing their occurrence, chemical structures, and origins. This resource aids researchers studying RNA modifications and their roles across different organisms.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Post-transcriptional modifications of RNA are crucial for gene expression regulation.
  • A comprehensive catalog of these modifications is essential for biological research.

Purpose of the Study:

  • To provide an updated and comprehensive online resource for RNA modifications.
  • To consolidate information on modified nucleosides from RNA.

Main Methods:

  • Compiling data from literature citations for structural characterization and occurrence.
  • Organizing information including RNA types, phylogenetic distribution, chemical names, registry numbers, and structures.
  • Making data accessible via the World Wide Web and anonymous ftp.

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Main Results:

  • The database offers a detailed listing of post-transcriptionally modified nucleosides.
  • Information includes phylogenetic distribution, chemical nomenclature, and structural data.
  • Literature citations for initial characterization, occurrence, and synthesis are provided.

Conclusions:

  • The RNA Modification Database serves as a vital, updated resource for the scientific community.
  • It facilitates research into the diversity and function of RNA modifications.
  • Accessible data supports advancements in molecular biology and genomics.