[Comparison of in vitro action of cetylpyridinium chloride containing preparations]

The fungicidal efficacy on Candida albicans of cetylpyridinium chloride (CAS 123-03-5) solution (CPC I solution, Dobendan) in various dilutions was tested with help of the quantitative suspension test and compared with CPC containing self-made preparations with or without addition of alcohol. The dilution of all test preparations caused an impairment of antimicrobial efficacy; the activity was reduced distinctly: due to a 50% dilution a decrease of 2-3 ten's powers was observed. The reduction of efficacy of the self-made preparation was less pronounced. The addition of 1% albumin as well impaired the fungicidal activity of all test preparations. CPC + alcohol revealed the most pronounced fungicidal efficacy; no differences were seen between CPC (without alcohol) and CPC I solution.