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Comparison of volume output from two different continuous nebulizer systems
Summary
Continuous nebulization for acute asthma treatment showed the small volume nebulizer system offers more consistent beta 2-adrenergic agonist delivery than large volume nebulizers.
Area of Science:
- Pulmonary Medicine
- Pharmacology
- Medical Devices
Background:
- Continuous nebulization is a recognized method for administering beta 2-adrenergic agonists in acute asthma.
- Two primary systems exist: large volume nebulizers and small volume nebulizers with infusion pumps.
Purpose of the Study:
- To compare the volume output characteristics of large volume and small volume nebulizer systems for continuous nebulization.
Main Methods:
- Both nebulizer types were reconstructed and their volume output monitored hourly over four hours.
- Nine nebulizers of each type, from three different lots, were evaluated.
Main Results:
- Large volume nebulizers exhibited variable output (mean 45.96 mL/h), with significant changes over time.
- Small volume nebulizers demonstrated consistent output (mean 15.88 mL/h), with minimal variation across time.
Conclusions:
- Small volume nebulizers appear more consistent for continuous nebulization compared to large volume nebulizers.
- Further research on drug output and particle characteristics is needed for definitive recommendations.