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Intercellular communication in the brain: wiring versus volume transmission
L F Agnati1, M Zoli, I Strömberg
1Department of Biomedical Sciences, University of Modena, Italy.
Neuroscience
|December 1, 1995
Summary
Central nervous system communication is classified into "wiring" transmission via direct connections and "volume" transmission through signal diffusion. This framework encompasses various cell types and transmission modalities in vertebrates.
Area of Science:
- Neuroscience
- Cell Biology
- Neuroanatomy
Background:
- Interneuronal communication concepts in the central nervous system (CNS) have evolved.
- Existing models primarily focus on synaptic transmission.
- A need exists for a broader classification of cell-to-cell signaling in neural tissue.
Purpose of the Study:
- To propose a new classification framework for CNS communication.
- To define and differentiate "wiring" and "volume" transmission.
- To review evidence for diverse intercellular communication mechanisms in the CNS.
Main Methods:
- Conceptual framework development.
- Literature review of existing research on intercellular communication.
- Analysis of phylogenetic, physiological, and pathological data.
Main Results:
- Introduction of two primary communication frames: "wiring" and "volume" transmission.
- "Wiring" transmission involves direct, identifiable structures (e.g., synapses, gap junctions).
- "Volume" transmission involves signal diffusion through extracellular and cerebrospinal fluid.
Conclusions:
- The proposed classification provides a comprehensive view of CNS communication.
- Both "wiring" and "volume" transmission involve various neural and glial cells.
- Understanding these modalities is crucial for comprehending CNS function in health and disease.