Related Experiment Video
Updated: Aug 10, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
Induction of protective CTL responses in newborn mice by a murine retrovirus
M Sarzotti1, D S Robbins, P M Hoffman
1Rsearch Service, Veterans Affairs Medical Center, Baltimore, MD 21201, USA.
Abstract:
The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.

