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Ascorbic acid and gastrointestinal cancer

M Cohen1, H N Bhagavan

  • 1Scientific Information Services, Hoffmann-La Roche, Nutley, NJ 07110, USA.

Journal of the American College of Nutrition
|December 1, 1995
PubMed
Summary
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Ascorbic acid shows promise in reducing gastric cancer risk, but evidence is weaker for other gastrointestinal cancers. More research is needed for esophageal, colorectal, and oral cancers, and precancerous conditions.

Area of Science:

  • Oncology
  • Nutritional Science
  • Gastroenterology

Background:

  • Gastrointestinal cancers represent a significant global health burden.
  • Ascorbic acid (vitamin C) is a widely studied antioxidant with potential chemopreventive properties.

Purpose of the Study:

  • To critically evaluate the efficacy of ascorbic acid in modulating the incidence of various gastrointestinal cancers.
  • To synthesize evidence from preclinical, clinical, and epidemiological studies.

Main Methods:

  • Comprehensive literature review.
  • Critical appraisal of diverse study types including preclinical, clinical, and epidemiological research.

Main Results:

  • Stronger evidence supports ascorbic acid's role in inhibiting gastric cancer carcinogenesis.

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  • Weaker evidence exists for ascorbic acid's effect on esophageal and colorectal cancer.
  • Insufficient evidence is available for oral cavity cancers and precancerous conditions like polyposis and leukoplakia.

    • Conclusions:

    • Ascorbic acid demonstrates potential as a chemopreventive agent, particularly for gastric cancer.
    • Further investigation is warranted for other gastrointestinal sites and precancerous lesions.