Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enterocyte functional adaptation following intestinal resection

E E Whang1, J C Dunn, H Joffe

  • 1Department of Surgery, UCLA School of Medicine, Los Angeles, California 90024, USA.

The Journal of Surgical Research
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells.

British journal of cancer·2025
Same author

Grey Partridge (<i>Perdix perdix</i>) Introductions: Genetic Survey on Wild and Captive Populations at the Edges of the Range.

Ecology and evolution·2025
Same author

Forest maturity has a stronger influence on the prevalence of spider monkeys than howler monkeys in an anthropogenically impacted rainforest landscape.

Primates; journal of primatology·2022
Same author

The evolution of mammalian brain size.

Science advances·2021
Same author

Epidemiology of gunshot wounds to the hand.

Hand surgery & rehabilitation·2018
Same author

Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS<sup>®</sup>) Society Recommendations: 2018.

World journal of surgery·2018
Same journal

Evaluation of Online Educational Content on Indocyanine Green Fluorescence for Flap Perfusion: Assessment of Quality, Reliability, and Engagement Metrics.

The Journal of surgical research·2026
Same journal

Protocolized Pain Assessment and Management in Pediatric Trauma Patients.

The Journal of surgical research·2026
Same journal

Noninvasive Cardiac Output Monitoring Combined With Critical Care Ultrasound for Postoperative Volume Management in Cardiac Surgery Patients: A Randomized Controlled Trial.

The Journal of surgical research·2026
Same journal

Emergency Surgical Cricothyrotomy Videos Online: Reliability and Training Quality Evaluation.

The Journal of surgical research·2026
Same journal

Management of Concomitant Traumatic Abdominal Vascular and Gastrointestinal Injuries: A Descriptive Study.

The Journal of surgical research·2026
Same journal

Article Processing Charges in General Surgery Journals: Implications for Equitable Publishing Access in Low-Income and Middle-Income Countries.

The Journal of surgical research·2026
See all related articles

Following small bowel resection, ileal surface area increases due to hyperplasia. However, individual enterocyte function diminishes, suggesting hyperplasia is key in early adaptation.

Area of Science:

  • Gastroenterology
  • Physiology
  • Surgical Research

Background:

  • Massive small bowel resection triggers compensatory intestinal adaptation to preserve absorptive capacity.
  • Understanding the mechanisms of this adaptation is crucial for managing post-surgical patients.

Purpose of the Study:

  • To differentiate the roles of mucosal hyperplasia and enterocyte functional adaptation in early post-small bowel resection adaptation.
  • To quantify the changes in absorptive surface area and nutrient transport in the remaining ileum.

Main Methods:

  • Rats underwent 70% small bowel resection or transection with reanastomosis.
  • Ileal tissue was analyzed 2 weeks post-surgery using Ussing chambers for transport studies.
  • Computer-assisted morphometric modeling assessed microvillus absorptive surface area.

Related Experiment Videos

Main Results:

  • Ileal absorptive surface area was significantly greater (70%) in the resection group compared to the transection group.
  • While surface area increased, normalized transport parameters (Na+, Cl-, glucose absorption) per unit area decreased in the resection group.
  • Na+/glucose cotransporter quantity (delta Isc max) was significantly lower in the resection group, indicating reduced transporter expression.

Conclusions:

  • Early adaptation after small bowel resection primarily involves an increase in ileal absorptive surface area through hyperplasia.
  • Functional adaptation of individual enterocytes, indicated by reduced nutrient transport per unit area, appears less significant in the early stages.
  • These findings highlight hyperplasia as the dominant mechanism driving compensatory adaptation post-resection.