Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homeostasis-securing therapy and statusmetria

G A Shifrin1

  • 1Institute of Physician Postdiploma Education, Department of Anaesthesiology and Reanimatology, Zaporozhye, Ukraine.

Acta Anaesthesiologica Scandinavica. Supplementum
|January 1, 1995
PubMed
Summary

Homeostasis-Securing Therapy (HST) offers a superior alternative to Syndrome Intensive Care (SIC) for treating Multiorgan System Failure (MOSF). HST demonstrated twice the survival rate by effectively restoring metabolic balance and regeneration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Fundamental s of anesthesiology-reanimation. Part II. Principles of training].

Klinichna khirurhiia·2001
Same author

[Fundamentals of anesthesiology-resuscitation. Part I. Methodology of the concept].

Klinichna khirurhiia·2001
Same author

[The luminescence of blood leukocytes, stained with the fluorochrome acridine orange, from surgical patients in the dynamics of emotional, anesthesiological and surgical stress].

TSitologiia i genetika·2000
Same author

[A concept of antinociceptive anesthesia].

Anesteziologiia i reanimatologiia·1993
Same author

[Pathophysiologic characteristics of the reactive toxic stage of acute suppurative peritonitis and ways to enhance the effectiveness of intensive therapy].

Patologicheskaia fiziologiia i eksperimental'naia terapiia·1989
Same author

[Early signs of decompression of the body in acute suppurative peritonitis and ways of increasing the effectiveness of intensive therapy].

Klinicheskaia khirurgiia·1989

Area of Science:

  • Critical Care Medicine
  • Physiology
  • Biomedical Engineering

Background:

  • Syndrome Intensive Care (SIC) has limited efficacy for Multiorgan System Failure (MOSF).
  • An alternative treatment approach is needed to improve patient outcomes.
  • Statusmetria provides effective oxygen status assessment.

Purpose of the Study:

  • To evaluate the efficacy of Homeostasis-Securing Therapy (HST) compared to SIC in patients with MOSF.
  • To determine if HST can improve survival rates by addressing energostructure deficits and restoring regeneration.
  • To introduce HST as an advanced treatment strategy for MOSF.

Main Methods:

  • Assessed treatment efficiency in 257 MOSF patients.
  • Monitored Oxygen Pulse (OP) and Index of Efficacy of Oxygen Transport (IETO2).

Related Experiment Videos

  • Defined HST by eliminating energostructure deficit and restoring regeneration rate.

    • Main Results:

    • SIC patients with MOSF had OP ≤ 0.8 mL.m⁻² and IETO2 = 2.4 units.
    • HST patients maintained OP of 1.0-1.7 mL.m⁻² and IETO2 of 1.9-2.4 units.
    • Survival rates were 30.4% (41/135) in SIC versus 78.7% (96/122) in HST.

    Conclusions:

    • Homeostasis-Securing Therapy (HST) is significantly more effective than Syndrome Intensive Care (SIC) for MOSF.
    • HST improves survival by restoring metabolic balance and regeneration.
    • HST represents a promising new technology for treating MOSF.