The many faces of squamous cell carcinoma

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Cutaneous squamous cell carcinoma (cSCC) encompasses diverse subtypes with varying clinical, histologic, and etiologic characteristics.
• Recognizing these subtypes is essential for effective clinical management.

Purpose of the Study:

• To present 10 common and clinically significant subtypes of cSCC.
• To highlight the clinical importance and contrasting features of each subtype.

Main Methods:

• A comprehensive literature review was conducted for each of the 10 selected cSCC subtypes.
• Key information regarding etiology, histology, and clinical presentation was synthesized.

Main Results:

• Each cSCC subtype possesses distinct characteristics that influence diagnosis and treatment.
• Understanding these unique features is fundamental for appropriate patient management.

Conclusions:

• The 10 common cSCC variants discussed have unique features impacting diagnosis, treatment, and management.
• Physicians must understand these specific characteristics for optimal patient care.