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On the mechanism by which 6-ketocholestanol protects mitochondria against uncoupling-induced Ca2+ efflux
E Chávez1, R Moreno-Sánchez, C Zazueta
1Departamento de Bioquimica, Instituto Nacional de Cardiología, Mexico.
FEBS Letters
|February 5, 1996
Abstract:
This work shows that 6-ketocholestanol (kCh) inhibits the effect of carbonyl cyanide-m-chlorophenyl hydrazone (CCP) on mitochondrial Ca2+ efflux. Such an effect proved to be caused by diminution of membrane fluidity, therefore, it is affected by the incubation temperature. Furthermore, kCh reversed CCP-induced Ca2+ efflux depending on the accumulation of phosphate. It is also shown that kCh enhances the effect of carboxyatractyloside on membrane permeability transition.