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Mortality in the rheumatic diseases

L F Callahan, T Pincus

    Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association
    |December 1, 1995
    PubMed
    Summary
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    Patients with rheumatic diseases, especially inflammatory types, face higher mortality rates. Severe clinical status predicts death, underscoring the disease

    Area of Science:

    • Rheumatology
    • Clinical Epidemiology

    Background:

    • Rheumatic diseases encompass a wide range of conditions affecting joints, muscles, and connective tissues.
    • Increased mortality has been a concern in patients diagnosed with various rheumatic conditions.

    Purpose of the Study:

    • To systematically review and synthesize mortality data from published studies on diverse rheumatic diseases.
    • To assess the magnitude of excess mortality associated with specific rheumatic conditions.

    Main Methods:

    • A comprehensive literature search was conducted using MEDLINE.
    • Studies included patients with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, scleroderma, polymyositis, and vasculitis.

    Main Results:

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  • Most rheumatic diseases are associated with higher-than-expected mortality rates.
  • Inflammatory rheumatic diseases show considerably elevated mortality.
  • Mortality in systemic lupus erythematosus, scleroderma, polymyositis, and vasculitis is comparable to that of neoplastic or cardiovascular diseases.

    • Conclusions:

    • Severe clinical status is a significant predictor of mortality in rheumatic diseases.
    • Deaths in patients with rheumatic diseases should not be presumed unrelated to their underlying condition.
    • Findings have implications for clinical management and health policy for rheumatic disease patients.