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Surgical options for familial adenomatous polyposis
W L Ambroze1, G R Orangio, G Lucas
1Department of Surgery, Medical College of Georgia, Atlanta.
Seminars in Surgical Oncology
|November 1, 1995
Summary
Familial adenomatous polyposis (FAP) is an inherited condition requiring early surgical intervention to prevent colon cancer. This review details surgical options for FAP patients, considering individual factors for optimal outcomes.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Genetics
Background:
- Familial adenomatous polyposis (FAP) is an autosomal dominant genetic disorder.
- Individuals with FAP have a high risk of developing colon cancer and extracolonic manifestations if untreated.
- Early detection and surgical management are crucial for FAP patients.
Purpose of the Study:
- To review the surgical options available for treating Familial adenomatous polyposis (FAP).
- To emphasize the specific indications, contraindications, and expected outcomes for each surgical procedure in FAP management.
Main Methods:
- Review of existing literature on surgical management of FAP.
- Analysis of factors influencing surgical decision-making in FAP patients.
Main Results:
- Surgical options for FAP include total proctocolectomy with ileostomy, continent ileostomy, total colectomy with ileorectal anastomosis, and total proctocolectomy with ileal pouch anal anastomosis.
- Patient-specific factors like rectal disease extent, carcinoma presence, sphincter function, and extracolonic disease significantly influence surgical choice.
Conclusions:
- The selection of surgical treatment for FAP must be individualized.
- Appropriate surgical intervention can significantly improve outcomes and prevent complications in FAP patients.