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Lung tumors with a rhabdoid phenotype
A Cavazza1, T V Colby, M Tsokos
1Department of Laboratory Medicine and Pathology, Mayo Clinic Scottsdale, Arizona 85259, USA.
American Journal of Clinical Pathology
|February 1, 1996
Summary
Rare malignant lung tumors with a rhabdoid phenotype present as advanced lung masses. Histology shows characteristic rhabdoid cells, with immunohistochemistry and electron microscopy aiding diagnosis.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Malignant tumors of the lung with a rhabdoid phenotype are exceptionally rare.
- These tumors typically present as lung masses in adults and are often locally advanced.
Purpose of the Study:
- To describe the clinicopathologic features of six malignant lung tumors exhibiting a rhabdoid phenotype.
- To highlight the diagnostic characteristics, including histology and immunohistochemistry.
Main Methods:
- Histologic examination to identify rhabdoid features (macronucleolated cells with eosinophilic inclusions).
- Immunohistochemistry for vimentin, epithelial, and neuroendocrine markers.
- Electron microscopy in one case.
Main Results:
- Six cases of lung tumors with rhabdoid phenotype were identified, ranging from 1.3 cm to 8.0 cm.
- Distinctive rhabdoid cells comprised at least 10% of the tumor population.
- Consistent vimentin positivity; focal epithelial and diffuse neuroendocrine marker positivity were observed.
Conclusions:
- Malignant lung tumors with a rhabdoid phenotype are rare, often poorly differentiated carcinomas.
- These tumors frequently display features suggestive of neuroendocrine differentiation.
- The characteristic rhabdoid morphology, supported by immunohistochemistry, is key for diagnosis.