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Long-term survival after bronchial sleeve resection: univariate and multivariate analyses
P E Van Schil1, A Brutel de la Riviére, P J Knaepen
1Department of Thoracic Surgery, University Hospital of Antwerp, Edegem, Belgium.
The Annals of Thoracic Surgery
|April 1, 1996
Summary
Long-term bronchial sleeve resection outcomes depend on nodal stage. Patients with N1 or N2 disease have significantly lower survival rates, often due to distant metastases.
Area of Science:
- Thoracic Surgery
- Surgical Oncology
- Pulmonary Medicine
Background:
- Long-term outcomes of bronchial sleeve resection are debated, particularly concerning lymph node involvement.
- Previous studies indicated no 10-year survivors among patients with N1 or N2 disease.
Purpose of the Study:
- To evaluate the long-term survival rates after bronchial sleeve resection.
- To identify prognostic factors influencing survival in patients undergoing this procedure.
Main Methods:
- A cohort of 145 patients who underwent bronchial sleeve resection for bronchogenic tumors between 1960 and 1989 was analyzed.
- Follow-up data extended to 1994, ensuring a minimum of 5 years for survivors.
- Univariate and multivariate analyses were performed to assess survival predictors.
Main Results:
- Overall 5-, 10-, and 15-year survival rates were 46%, 33%, and 22%, respectively, with a median survival of 53 months.
- Survival rates varied significantly by nodal stage: 62% (5-year) and 51% (10-year) for no nodal disease, 31% (5-year) and 10% (10-year) for N1 disease, and 31% (5-year) and 13% (7-year) for N2 disease.
- Nodal stage and patient age were identified as significant factors influencing survival in multivariate analysis.
Conclusions:
- Nodal stage is the primary determinant of long-term survival following bronchial sleeve resection.
- Patients with N1 and N2 disease exhibit substantially reduced survival, frequently succumbing to distant metastatic disease.