[Histogenesis and mechanism of regression of congenital cutaneous angiomas in children (electron-microscopic study)]

The ultrastructure of hemangiomas of the skin was investigated in 4 children at the age of 3 to 6 months. Histologically, the hemangiomas were represented by hypertrophic and capillar forms. Tumour cells, both those forming walls of capillaries and distributed between capillaries, were similar with respect to their ultrastructure and analogous to the endothelial cells they originated from. Capillaries and cells were "immured" with fibrillary substance which was produced by the tumour cells themselves. In intercellular and intercapillary areas there were also observed fibroblasts and collagenous fibres. Many cells of the tumour underwent necrosis. The cause of destruction of tumour cells resulting in regression of angiomas was fibrosis, the development of which was associated with the activity of the tumour cells themselves and fibroblasts.