Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Zinc and the growth hormone system]

S Ripa1, R Ripa

  • 1Istituto di Clinica Medica Generale, Università degli Studi, Ferrara.

Minerva Medica
|January 1, 1996
PubMed
Summary

Zinc deficiency stunts growth by reducing insulin-like growth factor-I (IGF-I) production and causing receptor resistance. Supplementation restores IGF-I levels and growth, highlighting zinc's crucial role.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibacterial activity of various antibiotics against oral streptococci isolated in the oral cavity.

International journal of immunopathology and pharmacology·2012
Same author

In vitro activity of cefditoren versus other antibiotics against S. pneumoniae clinical strains isolated in Italy.

International journal of immunopathology and pharmacology·2010
Same author

Antibacterial activity and anti-biofilm effect of chitosan against strains of Streptococcus mutans isolated in dental plaque.

International journal of immunopathology and pharmacology·2009
Same author

Analysis of different genetic traits and their association with biofilm formation in Staphylococcus epidermidis isolates from central venous catheter infections.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2006
Same author

Distribution of mef(A)-containing genetic elements in erythromycin-resistant isolates of Streptococcus pyogenes from Italy.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2005
Same author

In vitro selection of resistance to clarithromycin in Streptococcus pneumoniae clinical isolates.

Journal of chemotherapy (Florence, Italy)·2005

Area of Science:

  • Endocrinology
  • Nutritional Science
  • Growth Biology

Context:

  • Chronic zinc deficiency is a known cause of impaired pondero-statural growth.
  • The pituitary gland's role in growth appears less significant than liver-derived factors in this context.

Purpose:

  • To investigate the mechanisms by which zinc deficiency affects physical growth.
  • To elucidate the role of zinc in regulating growth hormone (GH) and insulin-like growth factor-I (IGF-I) synthesis and action.

Summary:

  • Zinc deficiency significantly reduces liver synthesis of IGF-I and causes receptor resistance to both GH and IGF-I, leading to growth delay.
  • Zinc supplementation increases IGF-I production and overcomes receptor resistance, restoring normal growth.
  • Zinc's action extends to the receptor level, potentially by increasing receptor number.

Impact:

  • This research clarifies zinc's critical role in mediating growth, particularly through IGF-I pathways.
  • Findings suggest zinc supplementation as a therapeutic strategy for growth disorders linked to mineral deficiency.
  • Understanding zinc's impact on receptor function provides new insights into endocrine regulation of growth.

Related Experiment Videos